News

 

June 2016
  • Two Postdoctoral Fellows (PDF) for a September 1, 2016 start date.

    Candidates should have demonstrated experience in Protein Chemistry and an interest in industrial product development settings. See the PDF for specific responsibilities and requirements.
July 2014
  • The lab welcomes Prashant Deore as a new Post-Doctoral fellow in the lab.
June 2014
  • Kaila gives an oral presentation and Anne gives a poster presentation at the 97th CSC in Vancouver, BC.
  • Congratulations to Dr. Aaron Witham for the successful defense of his PhD thesis entitled "Structural Analysis of Detrimental Oxidative Products from Phenolic Carcinogens and Construction of Nucleotide Tools from Analogous Processes"
May 2014
  • Congratulations to Dr. Michael Sproviero for the successful defense of his PhD thesis entitled "Characterization of Fluorescent 8-Aryl-Guanine Mimics: From Mutagenic Lesions to Probes for Aptasensor Development"

September 2013

  • The laboratory welcomes Mr. Darian Blanchard and Mr. Thomas Cservenyi, as new masters students.
  • Welcome to new undergraduates working on their 4th year projects in the lab; Adam, Joe, and Mike.
June 2013
  • Congratulations to Kaila for winning first place in the Biological and Medicinal Chemistry Poster session at the CSC for her poster "Push-Pull 2'-Deoxyguanosine Adducts for Use as Turn-On Emissive Nucleoside Probes"
  • Congratulations to Florence for winning a book award in the Nucleic Acid Poster subdivision at the CSC for her poster “Synthesis and Properties of Duplex DNA Containing Oxygen-Linked Deoxyguanosine Adducts Derived from Phenolic Carcinogens”
May 2013
  • Congratulations to Michael S. Kuska for a successful defense of his MSc. thesis entitled "Structure and Stability of Oxygen-Linked DNA Adducts Derived from Phenolic Toxins"
  • Best wishes to Anne, who is spending the next 3 months at the ETH in Zurich working with our collaborator Dr. Shana Sturla.
  • Welcome to new students working in the lab over the summer, Ranjan, Rachael and Darian.
  • Richard gives an oral presentation at the 96th CSC in Quebec City.
  • Aaron, Mike S, Kaila, and Florence give poster presentations at the 96th CSC in Quebec City.
March 2013
  • Anne successfully presented her MSc. proposal entitled "Mutagenic Properties of Oligonucleotides Containing a C8-Aryl-Guanine Lesion"
  • Congratulations to Kaila for successfully completing her PhD. Comprehensive Exam.
February 2013
  • The laboratory welcomes Ms. Florence Berger, MSc student at the ETH in Zurich, as an exchange student.
December 2012
  • Congratulations to Dr. Katherine M. Rankin for successful defense of her PhD thesis entitled "Structure and Properties of C8-Aryl-2'-Deoxyguansone Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA".
  • Katies first-authored JOC publication is chosen as a Featured Article.
November 2012
  • Richard, Kaila, Mike K and Mike S attend the 40th Ontario-Quebec POMS at Queen's University, Kingston, Ontario. Kaila, Mike K and Mike S present posters with Mike S winning the prize for best poster.

 

August 2012
  • Mike S and Katie R present posters at the XX International Roundtable on Nucleosides, Nucleotides and Nucleic Acids in Montreal, Quebec and Katie wins a poster prize.
  • The laboratory welcomes Professor Mei Li, School of the Environment, Nanjing University, Nanjing, China, as a Visiting Scholar

 

May 2012

  • Mike S. and Richard give oral presentations at 95th CSC in Calgary
  • Katie, Aaron and Mike K. give poster presentations at 95th CSC in Calgary

 

March 2012

  • Undergraduate (4900) student Rachelle Humphries gives an oral presentation at the 40th SOUSCC at the University of Guelph

 

December 2011

  • Richard and family return from France!

 

June 2011

  • Katie gives an oral presentation at the 94th CSC in Montreal, QB
  • Mike S. and Aaron give oral presentations at the 94th CSC in Montreal, QB
  • Katie wins the Nucleic Acids in Chemistry and Biology Division Presentation Award for oral presentation given at the 94th CSC
  • Alireza successfully defends his Ph.D. thesis
  • Katie gets married on June 25th, 2011!
  • Richard and family leave for France for his sabbatical

 

March 2011

  • Undergraduate (4900/4910) students Kaila Fadock and Patricia Sobczyk give oral presentations at the 39th SOUSCC at the University of Waterloo
  • Kaila wins an Honourable Mention for her presentation at the 39th SOUSCC
  • Katie wins the University of Guelph Class of OAC ’60 Award for Outstanding Teaching Assistant

 

February 2011

  • Mike wins the University of Guelph Harold Suderman Laboratory Instructor Award

 

January 2011

  • Alireza’s work is highlighted on the cover of JACS
Manderville's JACS Journal Cover

"Postsynthetic Guanine Arylation of DNA by Suzuki-Miyaura Cross-Coupling"

 

Abstract: Direct radical addition reactions at the C8-site of 2′-deoxyguanosine (dG) can afford C8-Ar-dG adducts that are produced by carcinogenic arylhydrazines, polycyclic aromatic hydrocarbons, and certain phenolic toxins. Such modified nucleobases are also highly fluorescent for sensing applications and possess useful electron transfer properties. The site-specific synthesis of oligonucleotides containing the C8-Ar-G adduct can be problematic. These lesions are sensitive to acids and oxidants that are commonly used in solid-phase DNA synthesis and are too bulky to be accepted as substrates for enzymatic synthesis by DNA polymerases. Using the Suzuki-Miyaura cross-coupling reaction, we have synthesized a number of C8-Ar-G-modified oligonucleotides (dimers, trimers, decamers, and a 15-mer) using a range of arylboronic acids. Good to excellent yields were obtained, and the reaction is insensitive to the nature of the bases flanking the convertible 8-Br-G nucleobase, as both pyrimidines and purines are tolerated. The impact of the C8-Ar-G lesion was also characterized by electrospray ionization tandem mass spectrometry, UV melting temperature analysis, circular dichroism, and fluorescence spectroscopy. The C8-Ar-G-modified oligonucleotides are expected to be useful substrates for diagnostic applications and understanding the biological impact of the C8-Ar-G lesion.

   
 
  • Aaron and Mike S. win OGSST awards

December 2010

  • Katie gives a poster presentation at the International Chemical Congress of Pacific Basin Societies (Pacifichem) Conference in Honolulu, HI

 

November 2010

  • Katie and Richard organize and host the 38th Ontario-Québec POMS at University at Guelph
  • Alireza and Aaron give poster presentations at 38th POMS

 

May 2010

  • Aaron wins the David Holden Memorial Scholarship
  • Katie gives a poster presentation at the 93rd CSC in Toronto, ON

 

February 2010

  • Katie wins the University of Guelph Harold Suderman Laboratory Instructor Award

 

November 2009

  • Katie and Aaron give poster presentations at the 37th Ontario-Québec POMS at University at Buffalo

 

May 2009

  • Katie’s first-authored JOC publication is chosen as a Featured Article
  • Alireza and Richard give oral presentations at the 92nd CSC in Hamilton, ON
  • Katie gives a poster presentation at the 92nd CSC in Hamilton, ON
  • Katie wins the Nucleic Acids Symposium Poster Award for poster presentation given at the 92nd CSC

 

March 2009

  • Katie wins NSERC Postgraduate Scholarship – Doctoral (PGS D3)

 

November 2008

  • Katie gives an oral presentation at the 36th Ontario-Québec POMS at University of Ottawa

 

September 2008

  • Aaron wins an OGSST award

 

April 2008

  • Jen successfully defends her M.Sc. thesis!
  • Rob successfully defends his M.Sc. thesis!

 

March 2008

  • Katie wins NSERC Postgraduate Scholarship – Master’s (PGS M)

 

November 2007

  • Katie and Jen give poster presentations at the 35th Ontario-Québec POMS at University of Waterloo

 

 

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